RetinaLyze AMD is an algorithm, which enables safe, efficient and fast screening for signs of AMD in both clinical and retail settings. The purpose of the RetinaLyze AMD algorithm is to make it accessible to perform and receive AMD screenings.

The algorithm analyzes fundus images and gives instant and easily understandable results. The entire process involves only the image from fundus cameras.

Before you continue reading about the RetinaLyze AMD algorithm, it would be a great idea to familiarize yourself with the eye disease, Age-related Macula Degeneration. Read more below.

What is RetinaLyze AMD?

RetinaLyze AMD is an algorithm in RetinaLyze that analyses a photograph of the retina, taken with a fundus camera, and find signs of changes (or lack of changes). In other words, RetinaLyze AMD screens a patient for signs of AMD. If the system finds changes, the patient is referred to an eye specialist for further examination and treatment. RetinaLyze AMD screens for signs of dry AMD (drusen specifically). 

Always use an Amsler's grid test and consider visual acuity along with symptoms when screening for wet AMD.

How to use RetinaLyze AMD 

Who to screen

People over 40 years of age the primary group of people, who at risk of developing AMD. Since AMD is a slowly developing disease, up to half of all AMD patients are unaware of their condition. Therefore, it may be a good idea to screen all patients/customers for AMD, specifically from an age of 45 and upwards.

Read about risk factors in the article about AMD here.

Initiating the analysis in the RetinaLyze WebApp

Please read the general Get Started guide before continuing, if you are new to the RetinaLyze Webapp.

  1. Upload the fundus photo as usual (manually or automatically)
  2. Initiate the analysis by clicking on "Run AMD analysis"

The result is displayed on the Overview page. If you'd like to see the resulting overlay, go to the Details-page by clicking on the image on the Overview-page.

Understanding the results

The result of the automated analysis is displayed in two parts.
One is a colour-representation of the severity of the changes found (Yellow or Green), the other is an overlay showing the changes found (if any).

Colour summary of result

Green result

Green indicates that no AMD-related changes have been found.

Yellow result

Yellow indicates that there are indications of AMD i.e. drusen have been found. 

AMD overlay

The AMD overlay marks changes, found by the algorithm, on the retina. The AMD overlay is available on the Photo details-page using the 'Toggle AMD-overlay'-button above the fundus images.

Above you see the same fundus image without markings (left) and with markings on the AMD-related changes (right).

Communicating the results & Taking action

In general

The RetinaLyze AMD algorithm and the result should be considered a tool for a screening or diagnostic process, and not a diagnosis in itself. A diagnosis for AMD, should always be carried out by an ophthalmologist.

The screening and information provided by the RetinaLyze AMD algorithm does not replace a consultation with an ophthalmologist, who will be able to give the patient/client a more complete assessment of their vision and general eye health.

Green result

It's important to convey the following:

  • A screening, not diagnosis, has been performed for signs of dry AMD.
  • No indication of dry AMD has been found and the client doesn't need to be referred to an ophthalmologist for further examination for AMD.
  • If the client is already attending regular checkups with an ophthalmologist, has a scheduled appointment with an ophthalmologist or shows signs/has symptoms of eye diseases, they should keep attending their appointment(s) and/or seek medical attention.

An example of a formal communication of a Green result to the customer could be the following:

"RetinaLyze has performed a screening for signs of AMD on a photo of your retina.

RetinaLyze AMD looks for changes related to AMD, such as drusen.

No immediate AMD-related changes were found.

On the basis of this analysis, there has not been found any reason to contact an ophthalmologist earlier than already scheduled."

Yellow result

It's important to convey the following:

  • A screening, not diagnosis, has been performed for for signs of Dry AMD.
  • An indication of AMD has been found.
  • The patient should contact an ophthalmologist in the near future (weeks) for further examination. It is recommended to be aware and notice any of the symptoms of AMD. The symptoms, which you should watch out for are: blurry or blind spots in your central/reading vision, straight lines appearing wavy, or reduced vision. If the patient experiences any of these symptoms, they should see an ophthalmologist as soon as possible.
  • If the client is already attending regular checkups with an ophthalmologist, has a scheduled appointment with an ophthalmologist or shows signs/has symptoms of eye diseases, they should keep attending their appointment(s) and/or seek medical attention.

An example of a formal communication of a Yellow result to the customer could be the following:

"RetinaLyze has performed a screening for signs of AMD on a photo of your retina.

RetinaLyze AMD looks for changes related to AMD, such as drusen.

AMD-related changes were found.

On the basis of this analysis, it is recommended to contact an ophthalmologist in the near future (weeks) for further examination. 

It is recommended to be aware and notice any of the symptoms of AMD. The symptoms, which you should watch out for are: blurry or blind spots in your central/reading vision, straight lines appearing wavy, or reduced vision. If you experience any of these symptoms, see an ophthalmologist as soon as possible."

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